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Usually, only 1 question is asked from New Drugs in competitive exams like AIIMS, PGI, NEET. Only JIPMER is one such exam where many questions are asked from this topic.

Pharmacology expert, Dr. Gobind Rai Garg advises doing this topic in the end. He says, if you are not particularly preparing for JIPMER exam, try to do this topic of new drugs only if you have already completed the syllabus of Pharmacology. So, don’t waste your time unless you have completed the basics of Pharmacology.

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NEW DRUGS APPROVED IN 2018

Below is a comprehensive list of new drugs approved in 2018. The table includes the name of the drug, mechanism, route and indication.

Drug

Mechanism

Route

Indication

Andexanet alpha

Bind to Factor Xa inhibitors

Intravenous

To reverse overdose of rivaroxaban and apixaban

Apalutamide

Andreogen receptor antagonist

Oral

Prostate carcinoma

Avatrombopag

Thrombopoietin receptor agonist

Oral

Thrombocytopenia in patients with chronic liver disease

Baloxavirmarboxil

Inhibit viral replication by inhibiting Cap-dependent endonuclease activity of viral polymerase

Oral

Single dose treatment of Acute uncomplicated influenza

Baricitinib

Janus Kinase inhibitor

Oral

Rheumatoid Arthritis

Bictegravir

Integrase inhibitor

Oral

HIV

Binimetinib

MET tyrosine kinase inhibitor

Oral

BRAF V600E or V600K mutation-positive malignant melanoma

Burosumab

Monoclonal antibody against FGF-23

Subcutaneous

X-linked hypophosphatemia

Cannabidiol

Unknown

Oral

Lennox Gastaut syndrome

Dravet Syndrome

Cemiplimab

Monoclonal antibody against Programmed Death receptor (PD-1)

Intravenous

Squamous cell carcinoma of skin

Cenegermin

Recombinant human nerve growth factor

Eye drops

Neurotrophic keratitis

Dacomitinib

EGFR tyrosine kinase inhibitor

Oral

Non-small cell lung cancer with EGFR exon 19 deletion or exon 21 L858R substitution mutations

Doravirine

Non-nucleoside Reverse Transcriptase Inhibitor

Oral

HIV

Duvelisib

 

Inhibitor of PI-3 kinase gamma and delta

Oral

Small lymphocytic lymphoma

Follicular lymphoma

Chronic lymphoid leukemia

Elagolix

 

GnRH antagonist

Oral

Pain associated with endometriosis

Elapegademase

Recombinant Adenosine deaminase enzyme

Intramuscular

Adenosine Deaminase-Severe Combined Immunodeficiency

Encorafenib

 

BRAF-Kinase Inhibitor

Oral

BRAF V600E or V600K mutation-positive malignant melanoma

Eravacycline

 

Inhibit protein synthesis like other tetracyclines

Intravenous

Complicated intra-abdominal infections

Erenumab

Monoclonal antibody against CGRP

Sc

Migraine prophylaxis

Fostamatinib disodium hexahydrate

Spleen tyrosine kinase inhibitor

Oral

ITP

Fremanezumab

 

Monoclonal antibody against CGRP

Subcutaneous

Migraine prophylaxis

Galcanezumab

Monoclonal antibody against CGRP

Subcutaneous

Migraine prophylaxis

Ibalizumab

MAb against CD4

Iv

HIV

Inotersen

Antisense oligonucleotide against transthyretin mRNA

Subcutaneous

Polyneuropathy of hereditary transthyretin-mediated amyloidosis

Ivosidenib

 

Isocitrate dehydrogenase 2 (IDH2) inhibitor

Oral

Acute myeloid leukemia with IDH2 mutation

Lanadelumab

 

Monoclonal antibody against plasma kallikrein

Subcutaneous

Hereditary Angioneurotic Edema

Lofexidine

Alpha 2 agonist

Oral

To decrease opioid withdrawal symptoms

Lusutrombopag

Thrombopoietin receptor agonist

Oral

Thrombocytopenia in patients with chronic liver disease

Lutetium lu 177 dotatate

 

Peptide receptor radionuclide therapy

Intravenous

Gastro-entero-pancreatic neuroendocrine tumors

Megalastat

 

Pharmacological chaperone for Alpha galactosidase

Oral

Fabry’s disease

Mogamulizumab

 

Monoclonal antibody against CCR-4

Intravenous

Mycosis fungoides

Sezary syndrome

Moxetumomabpasudutox

 

Monoclonal antibody against CD22 conjugated with Pseudomonas exotoxin

Intravenous

Hairy cell leukemia

Moxidectin

 

Bind to Glutamate and GABA chloride channels

Oral

Onchocerciasis

Omadacycline

 

Inhibit protein synthesis like other tetracyclines

Oral

Intravenous

Community acquired bacterial pneumonia

Acute skin and skin structure infections

Patisiran

 

Small Interfering RNA based therapy against mutant transthyretin

Intravenous

Polyneuropathy in patients with transthyretin mediated amyloidosis

Pegvailase

Substitute of Phenylalanine hydroxylase

Sc

Phenylketonuria

Plazomicin

 

Inhibit protein synthesis like other aminoglycosides

Intravenous

Complicated UTI

Sarecycline

 

Inhibit protein synthesis like other tetracyclines

Oral

Inflammatory lesions of non-nodular moderate to severe acne

Segesterone  + ethinyl estradiol

Inhibit ovulation

Vaginal ring

Contraception (once yearly)

Sodium zirconium cyclosilicate

Binds to K and increase fecal excretion

oral

Hyperkalemia

Stiripentol

 

Increases GABAergic activity

Oral

Dravet Syndrome

Talazoparib

PARP inhibitor

Oral

breast cancer with a germline BRCA mutation

Tecovirimat

 

Inhibit formation of extracellular viral forms

Oral

Small pox

Tefenaquine

 

Free radical mediated killing of hypnozooites

Oral

Single dose radical cure of P. vivax malaria

Tildrakizumab

MAb against IL-23

Sc

Plaque Psoriasis

Tizacaftor + ivacaftor

CFTR  stimulator and potentiator

Oral

Cystic fibrosis

Tolvaptan

Vasopressin V2 receptor antagonist

Oral

To slow kidney function decline in adult polycystic kidney disease

 

Here's how you can easily learn the New Drugs approved in 2018

 

For more such mnemonics on new drugs download the "Pharmacology by Dr. Gobind Rai Garg" app. 

For Android- Click Here

For iOS - Click Here 

 

To go through the detailed video discussion on:

'New Drugs Approved in 2018'- Click Here

'New Drugs Approved in 2017'- Click Here

 

Good Luck!

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