After sharing the complete list of New Drugs approved by the FDA in 2019, we have now up with a segregated list of important drugs. This list has been compiled by
Dr. Gobind Rai Garg keeping in mind the upcoming AIIMS Nov exam.
2021 Dream Pack: Clinical | Integrated | NEXT Ready
DRUGS FOR AIIMS NOV 2019
The table includes the name of the drug, mechanism, route and indication.
Drug |
Mechanism |
Route |
Indication |
Afamelanotide |
Melanocortin 1 receptor agonist |
Subcutaneous |
Phototoxicity in patients with erythropoietic protoporphyria |
Andexanet alpha |
Bind to Factor Xa inhibitors |
Intravenous |
To reverse overdose of rivaroxaban and apixaban |
Apalutamide Darolutamide |
Androgen receptor antagonist |
Oral |
Prostate carcinoma |
Avatrombopag Lusutrombopag |
Thrombopoietin receptor agonist |
Oral |
Thrombocytopenia in patients with chronic liver disease |
Baloxavir marboxil |
Inhibit viral replication by inhibiting Cap-dependent endonuclease activity of viral polymerase |
Oral |
Single dose treatment of Acute uncomplicated influenza |
Baricitinib |
Janus Kinase inhibitor |
Oral |
Rheumatoid Arthritis |
Bremelanotide |
Melanocortin receptor agonist |
subcutaneous |
Hypoactive sexual desire disorder in females |
Brexanolone |
GABA-A modulator |
Intravenous |
Post partum depression |
Caplacizumab |
vWF-directed antibody fragment |
IV/SC |
Thrombotic Thrombocytopenic Purpura |
Elagolix
|
GnRH antagonist |
Oral |
Pain associated with endometriosis |
Erenumab Fremanezumab Galcanezumab |
Monoclonal antibody against CGRP |
SC |
Migraine prophylaxis |
Esketamine |
Non-competitive NMDA antagonist |
Intranasal |
Treatment resistant depression |
Ibalizumab |
MAb against CD4 |
IV |
HIV |
Inotersen |
Antisense oligonucleotide against transthyretin mRNA |
Subcutaneous |
Polyneuropathy of hereditary transthyretin-mediated amyloidosis |
Istradefylline |
Adenosine A2 receptor antagonist |
Oral |
Off episode in Parkinsonism |
Lasmiditan |
5HT1F agonist |
Oral |
Acute severe migraine |
Lofexidine |
Alpha 2 agonist |
Oral |
To decrease opioid withdrawal symptoms |
Megalastat
|
Pharmacological chaperone for Alpha galactosidase |
Oral |
Fabry’s disease |
Moxidectin
|
Bind to Glutamate and GABA chloride channels |
Oral |
Onchocerciasis |
Netarsudil + Latanoprost |
Netarsudil: Rho kinase inhibitor Latanoprost: PGF2 apha |
Topical |
Open angle glaucoma |
Patisiran
|
Small Interfering RNA based therapy against mutant transthyretin |
Intravenous |
Polyneuropathy in patients with transthyretin mediated amyloidosis |
Pitolisant |
H3 antagonist/inverse agonist |
Oral |
Narcolepsy |
Pretomanid |
Inhibit mycolic acid synthesis |
Oral |
For XDR and MDR TB (in combination with bedaquiline and linezolide) |
Ravulizumab |
C5 Complement inhibitor |
Intravenous |
Paroxysomal Nocturnal Hemoglobinuria |
Romosozumab |
MAb against sclerostin |
Subcutaneous |
Post-menopausal osteoporosis |
Selinexor |
Selective inhibitor of nuclear export |
Oral |
Multiple myeloma Diffuse large B cell lymphoma |
Semaglutide |
GLP-1 agonist |
Oral |
Type 2 diabetes mellitus |
Solriamfetol |
DA and NA reuptake inhibitor |
Oral |
For excessive day time sleepiness in Obstructive sleep apnea and Narcolepsy |
Stiripentol
|
Increases GABAergic activity |
Oral |
Dravet Syndrome |
Tafenoquine |
Free radical mediated killing of hypnozooites |
Oral |
Single dose radical cure of P. vivax malaria |
Tecovirimat
|
Inhibit formation of extracellular viral forms |
Oral |
Small pox |
Tenapanor |
NHE-3 inhibitor |
Oral |
IBS with constipation |
Tolvaptan |
Vasopressin V2 receptor antagonist |
Oral |
To slow kidney function decline in adult polycystic kidney disease |
We hope this list will surely prove helpful to you for the upcoming AIIMS exam.