Afamelanotide

Melanocortin 1 receptor agonist

Subcutaneous

Phototoxicity in patients with erythropoietic protoporphyria

Andexanet alpha

Bind to Factor Xa inhibitors

Intravenous

To reverse overdose of rivaroxaban and apixaban

Apalutamide

Darolutamide

Androgen receptor antagonist

Oral

Prostate carcinoma

Avatrombopag

Lusutrombopag

Thrombopoietin receptor agonist

Oral

Thrombocytopenia in patients with chronic liver disease

Baloxavir marboxil

Inhibit viral replication by inhibiting Cap-dependent endonuclease activity of viral polymerase

Oral

Single dose treatment of Acute uncomplicated influenza

Baricitinib

Janus Kinase inhibitor

Oral

Rheumatoid Arthritis

Bremelanotide

Melanocortin receptor agonist

subcutaneous

Hypoactive sexual desire disorder in females

Brexanolone

GABA-A modulator

Intravenous

Post partum depression

Caplacizumab

vWF-directed antibody fragment

IV/SC

Thrombotic Thrombocytopenic Purpura

Elagolix

GnRH antagonist

Oral

Pain associated with endometriosis

Erenumab

Fremanezumab

Galcanezumab

Monoclonal antibody against CGRP

SC

Migraine prophylaxis

Esketamine

Non-competitive NMDA antagonist

Intranasal

Treatment resistant depression

Ibalizumab

MAb against CD4

IV

HIV

Inotersen

Antisense oligonucleotide against transthyretin mRNA

Subcutaneous

Polyneuropathy of hereditary transthyretin-mediated amyloidosis

Istradefylline

Adenosine A2 receptor antagonist

Oral

Off episode in Parkinsonism

Lasmiditan

5HT1F agonist

Oral

Acute severe migraine

Lofexidine

Alpha 2 agonist

Oral

To decrease opioid withdrawal symptoms

Megalastat

Pharmacological chaperone for Alpha galactosidase

Oral

Fabry’s disease

Moxidectin

Bind to Glutamate and GABA chloride channels

Oral

Onchocerciasis

Netarsudil + Latanoprost

Netarsudil: Rho kinase inhibitor

Latanoprost: PGF2 apha

Topical

Open angle glaucoma

Patisiran

Small Interfering RNA based therapy against mutant transthyretin

Intravenous

Polyneuropathy in patients with transthyretin mediated amyloidosis

Pitolisant

H3 antagonist/inverse agonist

Oral

Narcolepsy

Pretomanid

Inhibit mycolic acid synthesis

Oral

For XDR and MDR TB (in combination with bedaquiline and linezolide)

Ravulizumab

C5 Complement inhibitor

Intravenous

Paroxysomal Nocturnal Hemoglobinuria

Romosozumab

MAb against sclerostin

Subcutaneous

Post-menopausal osteoporosis

Selinexor

Selective inhibitor of nuclear export

Oral

Multiple myeloma

Diffuse large B cell lymphoma

Semaglutide

GLP-1 agonist

Oral

Type 2 diabetes mellitus

Solriamfetol

DA and NA reuptake inhibitor

Oral

For excessive day time sleepiness in Obstructive sleep apnea and Narcolepsy

Stiripentol

Increases GABAergic activity

Oral

Dravet Syndrome

Tafenoquine

Free radical mediated killing of hypnozooites

Oral

Single dose radical cure of P. vivax malaria

Tecovirimat

Inhibit formation of extracellular viral forms

Oral

Small pox

Tenapanor

NHE-3 inhibitor

Oral

IBS with constipation

Tolvaptan

Vasopressin V2 receptor antagonist

Oral

To slow kidney function decline in adult polycystic kidney disease