Pharmacology expert, Dr. Gobind Rai Garg has come up with a list of important 'New Drugs'. This list has been compiled keeping in mind the upcoming AIIMS-PG exam.
After going through this blog, you'll be well versed to answer any question related to this topic in the exam.
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IMPORTANT DRUGS FOR AIIMS-PG
The table includes the name of the drug, mechanism, route, and indication.
|
Drug |
Mechanism |
Route |
Indication |
|
Andexanet alpha |
Bind to Factor Xa inhibitors |
Intravenous |
To reverse overdose of rivaroxaban and apixaban |
|
Brexanolone |
GABA-A modulator |
Intravenous |
Post partum depression |
|
Baloxavirmarboxil |
Inhibit viral replication by inhibiting Cap-dependent endonuclease activity of viral polymerase |
Oral |
Single dose treatment of Acute uncomplicated influenza |
|
Elagolix
|
GnRH antagonist |
Oral |
Pain associated with endometriosis |
|
Esketamine |
Non-competitive NMDA antagonist |
Intranasal |
Treatment resistant depression |
|
Ibalizumab |
MAb against CD4 |
Intravenous |
HIV |
|
Pretomanid |
Inhibit mycolic acid synthesis |
Oral |
For XDR and MDR TB (in combination with bedaquiline and linezolid) |
|
Pitolisant |
H3 antagonist/inverse agonist |
Oral |
Narcolepsy |
|
Tenapanor |
Sodium hydrogen exchanger-3 (NHE-3) inhibitor |
Oral |
IBS with constipation |
|
Tafenoquine |
Free radical mediated killing of hypnozoites |
Oral |
Single dose radical cure of P. vivax malaria |
|
Lemborexant |
Dual Orexin Antagonist (DORA)- binds to both the orexin receptors OX1R and OX2R |
Oral |
Insomnia |
| Remdesivir | Remdesivir triphosphate inhibits viral RNA dependent RNA polymerase | Intravenous |
Coronavirus disease 2019 (COVID-19) |
| Ubrogepant | CGRP receptor antagonist | Oral | Acute treatment of migraine with or without aura |
| Rimegepant | CGRP receptor antagonist | Oral | Acute treatment of migraine with or without aura |
| Lasmiditan | 5HT1F agonist | Oral | Acute treatment of migraine with or without aura |
|
Erenumab
|
Monoclonal antibody against CGRP receptor | SC | Migraine prophylaxis |
| Galcanezumab | Monoclonal antibody against CGRP receptor | SC | Migraine prophylaxis |
| Fremanezumab | Binds to CGRP ligand blocking its binding to CGRP receptor. | SC | Migraine prophylaxis |
| Eptinezumab | Binds to CGRP ligand blocking its binding to CGRP receptor. | Intravenous | Migraine prophylaxis |
| Romosozumab | MAB against sclerostin | SC | Osteoporosis in postmenopausal women at high risk of fracture |
To enhance your understanding, watch the video on Must Know 'New Drugs' by Dr. Gobind Rai Garg:
Good Luck!
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