Pharmacology expert, Dr. Gobind Rai Garg has come up with a list of important 'New Drugs'. This list has been compiled keeping in mind the upcoming AIIMS-PG exam.

After going through this blog, you'll be well versed to answer any question related to this topic in the exam.

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IMPORTANT DRUGS FOR AIIMS-PG

The table includes the name of the drug, mechanism, route, and indication.

Drug

Mechanism

Route

Indication

Andexanet alpha

Bind to Factor Xa inhibitors

Intravenous

To reverse overdose of rivaroxaban and apixaban

Brexanolone

GABA-A modulator

Intravenous

Post partum depression

Baloxavirmarboxil

Inhibit viral replication by inhibiting Cap-dependent endonuclease activity of viral polymerase

Oral

Single dose treatment of Acute uncomplicated influenza

Elagolix

 

GnRH antagonist

Oral

Pain associated with endometriosis

Esketamine

Non-competitive NMDA antagonist

Intranasal

Treatment resistant depression

Ibalizumab

MAb against CD4

Intravenous

HIV

Pretomanid

Inhibit mycolic acid synthesis

Oral

For XDR and MDR TB (in combination with bedaquiline and linezolid)

Pitolisant

H3 antagonist/inverse agonist

Oral

Narcolepsy

Tenapanor

Sodium hydrogen exchanger-3 (NHE-3) inhibitor

Oral

IBS with constipation

Tafenoquine

Free radical mediated killing of hypnozoites

Oral

Single dose radical cure of P. vivax malaria

Lemborexant

Dual Orexin Antagonist (DORA)- binds to both the orexin receptors OX1R and OX2R

Oral

Insomnia

Remdesivir Remdesivir triphosphate inhibits viral RNA dependent RNA polymerase Intravenous

Coronavirus disease 2019

(COVID-19)

Ubrogepant CGRP receptor antagonist Oral Acute treatment of migraine with or without aura
Rimegepant CGRP receptor antagonist Oral Acute treatment of migraine with or without aura
Lasmiditan 5HT1F agonist Oral Acute treatment of migraine with or without aura

Erenumab

 

Monoclonal antibody against CGRP receptor SC Migraine prophylaxis
Galcanezumab Monoclonal antibody against CGRP receptor SC Migraine prophylaxis
Fremanezumab Binds to CGRP ligand blocking its binding to CGRP receptor. SC Migraine prophylaxis
Eptinezumab Binds to CGRP ligand blocking its binding to CGRP receptor. Intravenous Migraine prophylaxis
Romosozumab MAB against sclerostin SC Osteoporosis in postmenopausal women at high risk of fracture

 

 To enhance your understanding, watch the video on Must Know 'New Drugs' by Dr. Gobind Rai Garg: 

 

Good Luck!

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